In Vitroandin VivoMelanogenesis Inhibition by Biochanin A fromTrifolium pratense
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چکیده
منابع مشابه
The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression.
Biochanin A is an isoflavone isolated from red clover (Trifolium pratense), and is a commercially available nutraceutical for women suffering from postmenopausal symptoms. Isoflavones resemble the structure of oestrogen, and display agonistic and antagonistic interactions with the oestrogen receptor. Overexposure of oestrogen is a major contributing factor in the development of breast cancer, a...
متن کاملGrowth inhibition of human endothelial cells by the phyto-oestrogen biochanin A, a metabolite of genistein.
This study examined the growth regulatory effects of a phyto-oestrogen, biochanin A, on a transformed human endothelial cell line ECV304 in vitro. Biochanin A was found to inhibit cell proliferation in a dose-dependent fashion and this effect was influenced by the concentration of serum present in the culture medium. In the absence of serum, the calculated IC50 of biochanin A was 0.18 +/- 0.1 m...
متن کاملThe role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A.
The basis for the differential sensitivity of cultured normal human mammary epithelial (HME) cells and a transformed human breast cancer MCF-7 cell line to growth inhibition by the isoflavone genistein and its 4'-methyl ether derivative, biochanin A, was examined. In HME cells genistein is 5-fold more potent as a growth inhibitor than biochanin A, whereas in MCF-7 cells biochanin A and genistei...
متن کاملInhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A
High morbidity and mortality associated with oral squamous cell carcinoma (OSCC) are largely attributable to late stage diagnosis. Despite significant advances in therapeutic strategies, the five-year survival rate for oral cancer remains at about 50%. A chemopreventive approach may be an effective alternative or adjunct to current therapies. Previous studies have shown anti-tumor effects of is...
متن کاملDegradation of the Isoflavone Biochanin A by Fusarium javanicum
Isoflavone, Biochanin A, Dihydrobiochanin A, Phenylacetic acids, Fusarium javanicum After a lag-phase of 1 h a mycelial suspension of Fusarium javanicum completely degraded 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A) to a series of transiently accumulating catabolites. The compounds were elucidated by spectroscopic techniques and are arranged in the first known degradative pathway for an i...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2011
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.100878